Isotretinoin is a drug similar to vitamin A (retinoid) and is used to treat moderate to severe acne. The drug is considered the last, and most effective, step in acne treatment and is used when other treatments have not had a satisfactory effect
Isotretinoin is taken as a capsule (often 1-3 capsules daily) over a period of 4-12 months. The treatment reduces several factors that contribute to the development of acne - including cell division, sebum production, bacterial growth and inflammation in the skin. There are strict requirements for the use of isotretinoin, as well as patient follow-up. You cannot be pregnant or breast-feeding as the medicine is very harmful to the foetus. Women must therefore use safe contraception and take a monthly pregnancy test. Regular blood tests are also taken to check that the body tolerates the treatment.
Most side effects when using isotretinoin are mild and go away after treatment ends. Almost all patients get dry and thinner skin, and often chapped lips. Eyes and nasal mucosa may also become dry. Headaches, concentration difficulties, joint and muscle stiffness are experienced by some. Psychiatric side effects, including depression, may occur. Most people get a slight sunburn during the treatment.